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The trial seeks to determine whether treating cancer based on these specific genetic changes is effective.

A limited time option for 500 newly enrolling patients to NCI-MATCH is to also enroll in a study called COMET (COMmunication and Education in Tumor Profiling).

Patients will complete a survey before and after they undergo tumor gene testing in MATCH.

The primary goal for MATCH is to determine the percentage of patients whose tumors have a complete or partial response to treatment, meaning the tumors shrink by a certain amount. Treatments will be considered promising if at least 16% of the patients in an arm have tumor shrinkage.

This threshold was chosen to reduce the chance that a treatment that is not working will appear promising while also improving the chance that a treatment that is working will appear promising.

In addition to the institutions belonging to the NCTN, NCI-MATCH will be open to all institutions and sites that participate in the NCI Community Oncology Research Program (NCORP).

For clinical trial tracking purposes, the NCI-MATCH trial is also referred to as EAY131 and as NCT02465060.

Patients with advanced solid tumors, lymphomas, or myeloma may be eligible for MATCH, once they have progressed on standard treatment for their cancer or if they have a rare cancer for which there is no standard treatment.